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$ Usual HIV protease includes two Cys residues, at positions sixty seven and $ninety five .$ Since chemical synthesis of proteins made up of Cys is technically hard, Wlodawer and colleagues substituted the synthetic amino acid L- $alpha$ -amino-n-butyric acid (Aba) for The 2 Cys residues within the protein. Inside the authors' terms, this was accomplished to "minimize synthetic troubles affiliated with Cys deprotection and relieve merchandise managing."
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The Grignard reagent isn't isolated. It can be fashioned in Alternative and utilised straight away in the specified response. The alkylmetal bond is very polar, Using the partial negative cost on the $mathrm C $ atom, that makes the C atom really nucleophilic.
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